Zofran

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Consumer Alert: Popular Anti-Nausea Drug Zofran Linked to Birth Defects

Zofran is an anti-nausea drug not FDA-approved for use during pregnancy, but often prescribed "off label" for morning sickness. It is associated with an increased risk of cleft palate and congenital heart defects.1

M. Anderka et al. Medications Used to Treat Nausea and Vomiting of Pregnancy and Risk of Selected Birth Defects. Birth Defects Res A Clin Mol Teratol. (Jan. 2012); JT Anderson et al. Ondansetron use in Early Pregnancy and the Risk of Congenital Malformations – A Register Based Nationwide Cohort Study. Pharmacoepidemiology and Drug Safety. (Oct. 2013)

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